| Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. | |
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MedLine Citation:
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PMID: 21430586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring the delivery of therapeutic agents that would permit technical optimization and enhanced therapeutic efficacy. OBJECTIVE: To determine whether a readily available small-molecule MRI contrast agent, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA), could effectively track the distribution of larger therapeutic agents. METHODS: Gd-DTPA was coinfused with the larger molecular tracer, I-labeled human serum albumin (I-HSA), during CED of an EGFRvIII-specific immunotoxin as part of treatment for a patient with glioblastoma. RESULTS: Infusion of both tracers was safe in this patient. Analysis of both Gd-DTPA and I-HSA during and after infusion revealed a high degree of anatomical and volumetric overlap. CONCLUSION: Gd-DTPA may be able to accurately demonstrate the anatomic and volumetric distribution of large molecules used for antitumor therapy with high resolution and in combination with fluid-attenuated inversion recovery (FLAIR) imaging, and provide additional information about leaks into cerebrospinal fluid spaces and resection cavities. Similar studies should be performed in additional patients to validate our findings and help refine the methodologies we used. |
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Authors:
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John H Sampson; Martin Brady; Raghu Raghavan; Ankit I Mehta; Allan H Friedman; David A Reardon; Neil A Petry; Daniel P Barboriak; Terence Z Wong; Michael R Zalutsky; Denise Lally-Goss; Darell D Bigner |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neurosurgery Volume: 69 ISSN: 1524-4040 ISO Abbreviation: Neurosurgery Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-10 Completed Date: 2011-12-07 Revised Date: 2012-02-03 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
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Languages: eng Pagination: 668-76 Citation Subset: IM |
Affiliation:
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Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. john.sampson@duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Astrocytoma / pathology, radionuclide imaging Brain Neoplasms / pathology, radionuclide imaging Combined Modality Therapy Contrast Media Convection Dose-Response Relationship, Drug Drug Delivery Systems Gadolinium DTPA / administration & dosage*, diagnostic use* Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods* Male Middle Aged Positron-Emission Tomography Serum Albumin, Radio-Iodinated / diagnostic use Tomography, Emission-Computed |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR024128-01/RR/NCRR NIH HHS; 1R25-NS065731-01/NS/NINDS NIH HHS; P50 NS020023-16/NS/NINDS NIH HHS; P50-NS020023/NS/NINDS NIH HHS; R25 NS065731-01/NS/NINDS NIH HHS; R37 CA011898-42/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Serum Albumin, Radio-Iodinated; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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