| Co-localization of excitatory and inhibitory transmitters in the brain. | |
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MedLine Citation:
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PMID: 18439218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To review the understanding about co-localisation of amino acid transmitters in the brain. RESULTS: The idea that neurons release the same transmitter at all their synapses is associated with Henry Dale and formulated as Dale's principle by John Eccles. This idea has been modified during the last years based on several studies showing that transmitters can co-exist at the same synapse. First, a large body of evidence was presented showing that a classical transmitter can be co-localized with different types of neuropeptides. Then, several studies showed that a synapse could co-release two classical transmitters. CONCLUSION: This review presents and discusses data from our laboratory showing co-release of glutamate/gamma-aminobutyric acid (GABA), aspartate/glutamate and aspartate/GABA from different types of hippocampal synapses. |
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Authors:
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V Gundersen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta neurologica Scandinavica. Supplementum Volume: 188 ISSN: 0065-1427 ISO Abbreviation: Acta Neurol. Scand., Suppl.c Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-28 Completed Date: 2008-08-22 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0370337 Medline TA: Acta Neurol Scand Suppl Country: Denmark |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Department of Anatomy and the CMBN, University of Oslo, Norway. vidar.gundersen@medisin.uio.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspartic Acid
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metabolism* Epilepsy / etiology, metabolism, pathology Glutamic Acid / metabolism* Humans Mossy Fibers, Hippocampal / metabolism*, pathology Synapses / metabolism*, pathology gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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