Document Detail


Co-infection ratios versus inflammation, growth factors and progression of early atheromas.
MedLine Citation:
PMID:  16725009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycoplasma pneumoniae (MP) and Chlamydophila pneumoniae (CP) antigens are encountered in complicated atheromas and may be implicated in the diversity of atherosclerotic lesions. Mycoplasma can downregulate the immune system, altering levels of inflammation, which may favor the proliferation of other co-infectious agents. In the present study we analyze whether initially stable human atheromas exhibit different ratios of MP/CP antigens compared to ongoing atheromatous lesions. Two groups were examined for the presence of inflammatory cells, macrophages, growth factors and infectious agents: Group I (GI), n=16, early stable atheromas, <4 CD68(+) macrophages/400 x field, showing a normal distribution and a fibrous cap; Group II (GII), n=14, growing atheromas, > or =4 CD68+ cells/400 x field, lacking a fibrous cap, showing a non-normal macrophage distribution. The amounts of CP (but not MP) antigens and lymphocytes in GI were significantly lower than in GII. MP/CP ratios were higher in GI. MP correlated with CP and PDGFB in GI (r=0.79 and r=0.83, p<0.001), but not in GII (r=-0.4 and r=-0.08, p=0.81). MP and CP antigens are already present in early atheromas, and a higher MP/CP ratio correlates with increased growth factors, lower inflammation and plaque stability.
Authors:
Maria L Higuchi; José M Góis; Marcia M Reis; Marilia H Higuchi-Dos-Santos; Jayme Diament; Januário M Sousa; José A F Ramires; Sérgio A Oliveira
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  114     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-26     Completed Date:  2006-08-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  338-44     Citation Subset:  IM    
Affiliation:
Heart Institute of Clinical Hospital, Medical School, University of São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, Bacterial / analysis
Antigens, CD / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Cell Count
Chlamydophila Infections / complications*
Chlamydophila pneumoniae / immunology,  isolation & purification*
Coronary Artery Disease / diagnosis*,  microbiology*,  pathology
Coronary Vessels / microbiology,  pathology
Disease Progression
Female
Humans
Immunohistochemistry
Inflammation / pathology
Macrophages / cytology,  pathology
Male
Middle Aged
Mycoplasma pneumoniae / immunology,  isolation & purification*
Platelet-Derived Growth Factor / metabolism
Pneumonia, Mycoplasma / complications*
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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