Document Detail

Co-existing Adenoid Cystic Carcinoma and Invasive Squamous Cell Carcinoma of the Uterine Cervix: a Rare Case Report and Literature Review.
MedLine Citation:
PMID:  25361940     Owner:  NLM     Status:  In-Data-Review    
Adenoid cystic carcinoma (ACC) is a rare cervical malignancy, and its coexistence with other malignancies in the uterine cervix is extremely rare. Here, we present a case of coexistence of ACC and invasive squamous cell carcinoma (SCC) of the uterine cervix, as well as a literature review. A 68-year-old Chinese woman with vaginal bleeding underwent a cervical cytology screening, cervical biopsy, and finally cervical conization. Subsequent pathological diagnoses of coexisting ACC and invasive SCC were rendered with a positive margin. Her status post-radiation therapy showed no recurrence or metastasis after a follow-up of 7 months. Immunohistochemical studies of the surgical specimen revealed that the ACC component exhibited a pattern distinct from the SCC component. ACC was collagen IV, S-100 and CK7 positive, and p63 and CK34βE12 (CK903) patchy positive; SCC was p63 and CK34βE12 (CK903) strongly and diffusely positive, while negative for collagen IV, S-100, and CK7. Both components were positive for high-risk human papilloma virus types 16 and 18, detected by in situ hybridization. This case is among very few previously described cases of coexisting ACC with invasive SCC in the uterine cervix.
Xiaohua Shi; Xiaoyan Chang; Huanwen Wu; Xinyu Ren; Tonghua Liu; Marilyn M Bui
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical and laboratory science     Volume:  44     ISSN:  1550-8080     ISO Abbreviation:  Ann. Clin. Lab. Sci.     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410247     Medline TA:  Ann Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  502-7     Citation Subset:  IM    
Copyright Information:
© 2014 by the Association of Clinical Scientists, Inc.
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