| Co-existence of Parkinson's disease and progressive supranuclear palsy: case report and a review of the literature. | |
| | |
MedLine Citation:
|
PMID: 20737180 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Idiopathic Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct clinicopathological entities characterized by α-synuclein and tau pathology, respectively. They have occasionally been reported to co-exist in the same patient. We describe a rare case of a 73-year-old Caucasian woman diagnosed as idiopathic PD 5 years before her death yet at autopsy had not only PD, but also PSP. Although this patient fulfilled clinical criteria for idiopathic PD and did not have supranuclear ophthalmoplegia, she had several atypical features, including early postural instability with falls, early dysphagia, and a relatively rapid course. In conclusion, this case and a literature review highlight the co-existence of synuclein and tau pathology in the same patient and demonstrate that multiple diagnoses may exist in patients presenting with parkinsonism. The clinical heterogeneity seen in parkinsonism may reflect the occurrence of combined pathology. |
| | |
Authors:
|
Kumar Abhinav; Laura Marsh; Barbara Crain; Stephen G Reich; Kevin Biglan |
Publication Detail:
|
Type: Journal Article Date: 2010-08-25 |
Journal Detail:
|
Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 32 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 159-63 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Frenchay Hospital, Bristol, UK, kumar.abhinav@doctors.org.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparison of an interferon-gamma release assay and tuberculin skin test in refractory inflammator...
Next Document: Temperature rise during Er:YAG cavity preparation of primary enamel.