Document Detail


Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy.
MedLine Citation:
PMID:  18377693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.
Authors:
Vummidi Giridhar Premkumar; Srinivasan Yuvaraj; Palanivel Shanthi; Panchanatham Sachdanandam
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of nutrition     Volume:  100     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2008-12-30     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1179-82     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, DR. A.L.M. Post-Graduate, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Agents, Hormonal / therapeutic use
Breast Neoplasms / drug therapy*,  genetics
DNA Methylation / drug effects*
DNA Repair Enzymes / drug effects*,  metabolism
DNA, Neoplasm / genetics
Dietary Supplements*
Female
Humans
Middle Aged
Niacin / therapeutic use
Poly(ADP-ribose) Polymerases / metabolism
Riboflavin / therapeutic use
Single-Blind Method
Tamoxifen / therapeutic use*
Ubiquinone / analogs & derivatives,  therapeutic use
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/DNA, Neoplasm; 10540-29-1/Tamoxifen; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 59-67-6/Niacin; 83-88-5/Riboflavin; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 6.5.1.-/DNA Repair Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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