Document Detail

Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats.
MedLine Citation:
PMID:  9001393     Owner:  NLM     Status:  MEDLINE    
We investigated the expression of the yeast Kex2 family endoproteases furin and PACE4, and brain natriuretic peptide (BNP) in the atrium and ventricle after infarction as well as the conversion of the BNP precursor gammaBNP to BNP-45. In a rat heart failure model, plasma BNP rose in two phases--first at day 3, and again at day 14. BNP mRNA, as measured by Northern blot analysis, increased strongly at day 3, then at days 14 and 28 less strongly in the atrium, and in the ventricle it increased weakly at day 3, then strongly at days 14 and 28. Furin mRNA showed the same pattern of expression as that of BNP message, whereas PACE4 message stayed unchanged after the infarction. Both furin and BNP were immunostained in the myocardium adjacent to the infarcted tissue. We suggest that after myocardial infarction, furin is co-expressed with BNP in both the atrium and ventricle, and that furin may be responsible for the conversion of gammaBNP to BNP-45.
Y Sawada; M Inoue; T Kanda; T Sakamaki; S Tanaka; N Minamino; R Nagai; T Takeuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  400     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-02-21     Completed Date:  1997-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  177-82     Citation Subset:  IM    
Department of Molecular Medicine, Gunma University School of Medicine, Maebashi, Japan.
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MeSH Terms
Blotting, Northern
Coronary Vessels
Endopeptidases / metabolism
Heart Atria / metabolism
Heart Ventricles / metabolism
Immunoenzyme Techniques
Myocardial Infarction
Natriuretic Peptide, Brain
Nerve Tissue Proteins / blood,  genetics,  metabolism*
Proprotein Convertases
Protein Processing, Post-Translational
RNA, Messenger
Rats, Wistar
Serine Endopeptidases / genetics,  metabolism*
Subtilisins / genetics,  metabolism*
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/RNA, Messenger; 114471-18-0/Natriuretic Peptide, Brain; EC 3.4.-/Endopeptidases; EC 3.4.-/Proprotein Convertases; EC 3.4.21.-/Pcsk6 protein, rat; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/Subtilisins; EC

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