Document Detail


Co-electrospun gelatin-poly(l-lactic acid) scaffolds: Modulation of mechanical properties and chondrocyte response as a function of composition.
MedLine Citation:
PMID:  24433895     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Bio-synthetic scaffolds of interspersed poly(l-lactic acid) (PLLA) and gelatin (GEL) fibers are fabricated by co-electrospinning. Tailored PLLA/GEL compositions are obtained and GEL crosslinking with genipin provides for the maintenance of good fiber morphology. Scaffold tensile mechanical properties are intermediate between those of pure PLLA and GEL and vary as a function of PLLA content. Primary human chondrocytes grown on the scaffolds exhibit good proliferation and increased values of the differentiation parameters, especially for intermediate PLLA/GEL compositions. Mineralization tests enable the deposition of a uniform layer of poorly crystalline apatite onto the scaffolds, suggesting potential applications involving cartilage as well as cartilage-bone interface tissue engineering.
Authors:
Paola Torricelli; Michela Gioffrè; Andrea Fiorani; Silvia Panzavolta; Chiara Gualandi; Milena Fini; Maria Letizia Focarete; Adriana Bigi
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Publication Detail:
Type:  Journal Article     Date:  2013-12-12
Journal Detail:
Title:  Materials science & engineering. C, Materials for biological applications     Volume:  36     ISSN:  1873-0191     ISO Abbreviation:  Mater Sci Eng C Mater Biol Appl     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101484109     Medline TA:  Mater Sci Eng C Mater Biol Appl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  130-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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