Document Detail

Co-culture of arbuscular mycorrhiza-like fungi (Piriformospora indica and Sebacina vermifera) with plant cells of Linum album for enhanced production of podophyllotoxins: a first report.
MedLine Citation:
PMID:  18427926     Owner:  NLM     Status:  MEDLINE    
Cell suspension cultures of Linum album were developed from internode portions of in vitro germinated plant in Gamborg's B5 medium supplemented with 0.4 mg naphthalene acetic acid/l. The highest biomass was 8.5 g/l with podophyllotoxin and 6-methoxypodophyllotoxin at 29 and 1.9 mg/l, respectively after 12 d cultivation. Co-cultures of L. album cells with axenically cultivable arbuscular mycorrhiza-like fungi, Piriformospora indica and Sebacina vermifera, were established for the first time. These enhanced podophyllotoxin and 6-methoxypodophyllotoxin production by about four- and eight-fold, respectively, along with a 20% increase in biomass compared to the control cultures.
Ashish Baldi; Abhishek Jain; Nishant Gupta; A K Srivastava; V S Bisaria
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Publication Detail:
Type:  Journal Article     Date:  2008-04-22
Journal Detail:
Title:  Biotechnology letters     Volume:  30     ISSN:  0141-5492     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-10-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1671-7     Citation Subset:  IM    
Plant Cell Culture Laboratory, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110 016, India.
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MeSH Terms
Coculture Techniques
Flax / cytology*,  enzymology,  growth & development
Mycorrhizae / cytology*
Phenylalanine Ammonia-Lyase / metabolism
Podophyllotoxin / analogs & derivatives,  biosynthesis*,  metabolism
Reg. No./Substance:
0/6-methoxypodophyllotoxin; 518-28-5/Podophyllotoxin; EC Ammonia-Lyase

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