Document Detail

Co-administration of cyclosporine an alleviates thioacetamide-induced liver injury.
MedLine Citation:
PMID:  15770714     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the effects of cyclosporine A (CsA) on thioacetamide (TAA)-induced liver injury.
METHODS: CsA was co-administrated (7.5 microg/kg body weight per day, i.p.) into rat to investigate the role of CsA on TAA-(200 mg/kg body weight per 3 d for 30 d, i.p.)induced liver injury.
RESULTS: The data show that TAA caused liver fibrosis in rat after 30 d of treatment. CsA alleviates the morphological changes of TAA-induced fibrosis in rat liver. The blood glutamyl oxaloacetic transaminase (GOT)/glutamyl pyruvic transaminase (GPT) in the TAA-injury group is elevated compared to that of the normal rat. Compared with the TAA-injury group, the blood GOT/GPT and TGFbeta1 (by RT-PCR analysis) are reduced in the CsA plus TAA-treated rat. The level of the transforming growth factor receptor I (TGFbeta-R1) in the CsA plus TAA-treated group shows higher than that in the TAA only group, but shows a lower level of the fibroblast growth factor receptor 4 (FGFR4) in the CsA plus TAA-treated group, when using the Western blot analysis. After immunostaining of the frozen section, TGFbeta-R1 and FGFR4 are more concentrated in rat liver after CsA plus TAA injury.
CONCLUSION: This result suggests that CsA has an alleviated effect on TAA-induced liver injury by increasing the multidrug resistance P-glycoprotein and could be through the regulation of TGFbeta-R1 and FGFR4.
Sabrina Fan; Ching-Feng Weng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-16     Completed Date:  2005-04-19     Revised Date:  2012-06-05    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1411-9     Citation Subset:  IM    
Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan, China.
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MeSH Terms
Activin Receptors, Type I / metabolism
Blotting, Western
Cyclosporine / pharmacology*
Immunosuppressive Agents / pharmacology*
Liver Cirrhosis / chemically induced*,  metabolism*,  pathology
P-Glycoprotein / metabolism
Polymerase Chain Reaction
Protein-Serine-Threonine Kinases
Receptor, Fibroblast Growth Factor, Type 4
Receptors, Fibroblast Growth Factor / metabolism
Receptors, Transforming Growth Factor beta / metabolism
Reg. No./Substance:
0/Immunosuppressive Agents; 0/P-Glycoprotein; 0/Receptors, Fibroblast Growth Factor; 0/Receptors, Transforming Growth Factor beta; 59865-13-3/Cyclosporine; 62-55-5/Thioacetamide; EC type I receptor; EC protein, rat; EC, Fibroblast Growth Factor, Type 4; EC Kinases; EC Receptors, Type I

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