| Co-administration of cyclosporine an alleviates thioacetamide-induced liver injury. | |
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MedLine Citation:
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PMID: 15770714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the effects of cyclosporine A (CsA) on thioacetamide (TAA)-induced liver injury. METHODS: CsA was co-administrated (7.5 microg/kg body weight per day, i.p.) into rat to investigate the role of CsA on TAA-(200 mg/kg body weight per 3 d for 30 d, i.p.)induced liver injury. RESULTS: The data show that TAA caused liver fibrosis in rat after 30 d of treatment. CsA alleviates the morphological changes of TAA-induced fibrosis in rat liver. The blood glutamyl oxaloacetic transaminase (GOT)/glutamyl pyruvic transaminase (GPT) in the TAA-injury group is elevated compared to that of the normal rat. Compared with the TAA-injury group, the blood GOT/GPT and TGFbeta1 (by RT-PCR analysis) are reduced in the CsA plus TAA-treated rat. The level of the transforming growth factor receptor I (TGFbeta-R1) in the CsA plus TAA-treated group shows higher than that in the TAA only group, but shows a lower level of the fibroblast growth factor receptor 4 (FGFR4) in the CsA plus TAA-treated group, when using the Western blot analysis. After immunostaining of the frozen section, TGFbeta-R1 and FGFR4 are more concentrated in rat liver after CsA plus TAA injury. CONCLUSION: This result suggests that CsA has an alleviated effect on TAA-induced liver injury by increasing the multidrug resistance P-glycoprotein and could be through the regulation of TGFbeta-R1 and FGFR4. |
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Authors:
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Sabrina Fan; Ching-Feng Weng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 11 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-16 Completed Date: 2005-04-19 Revised Date: 2012-06-05 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1411-9 Citation Subset: IM |
Affiliation:
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Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activin Receptors, Type I
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metabolism Animals Blotting, Western Cyclosporine / pharmacology* Immunohistochemistry Immunosuppressive Agents / pharmacology* Liver Cirrhosis / chemically induced*, metabolism*, pathology Male P-Glycoprotein / metabolism Polymerase Chain Reaction Protein-Serine-Threonine Kinases Rats Receptor, Fibroblast Growth Factor, Type 4 Receptors, Fibroblast Growth Factor / metabolism Receptors, Transforming Growth Factor beta / metabolism Thioacetamide* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 0/P-Glycoprotein; 0/Receptors, Fibroblast Growth Factor; 0/Receptors, Transforming Growth Factor beta; 59865-13-3/Cyclosporine; 62-55-5/Thioacetamide; EC 2.7.1.11/TGF-beta type I receptor; EC 2.7.10.1/Fgfr4 protein, rat; EC 2.7.10.1/Receptor, Fibroblast Growth Factor, Type 4; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/Activin Receptors, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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