| Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats. | |
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MedLine Citation:
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PMID: 18430428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague-Dawley rats. Four groups of animals were fed a cornstarch-casein-sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100mgkg(-1)bodyweightd(-1)), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% (p=0.067) and non-HDL-cholesterol (non-HDL-C) by 29% (p=0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% (p=0.0002) and non-HDL-C by 59% (p<0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control (p=0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol (p=0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. |
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Authors:
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Xiaoming Jia; Yanfeng Chen; Jeffrey Zidichouski; Junzeng Zhang; Changhao Sun; Yanwen Wang |
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Publication Detail:
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Type: Journal Article Date: 2008-03-16 |
Journal Detail:
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Title: Atherosclerosis Volume: 201 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 101-7 Citation Subset: IM |
Affiliation:
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Institute for Nutrisciences and Health, National Research Council of Canada, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anticholesteremic Agents / administration & dosage* Berberine / administration & dosage* Cholesterol / blood* Diet, Atherogenic Drug Therapy, Combination Lipoproteins / blood Male Phytosterols / administration & dosage* Rats Rats, Sprague-Dawley Sitosterols / administration & dosage* Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Lipoproteins; 0/Phytosterols; 0/Sitosterols; 0/Triglycerides; 2086-83-1/Berberine; 474-60-2/campestanol; 57-88-5/Cholesterol; 83-45-4/stigmastanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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