Document Detail

CnrN regulates Dictyostelium group size using a counting factor-independent mechanism.
MedLine Citation:
PMID:  19704889     Owner:  NLM     Status:  PubMed-not-MEDLINE    
One of the simplest examples of a complex behavior is the aggregation of solitary Dictyostelium discoideum amoebae to form a 20,000-cell fruiting body. A field of starving amoebae first breaks up into territories. In each territory, the cells form a spider-like pattern of streams of cells. As part of a negative feedback loop, counting factor (CF), a secreted protein complex whose concentration increases with the size of the stream, prevents over-sized fruiting bodies from being formed by increasing cell motility and decreasing cell-cell adhesion, which causes the breakup of excessively large streams. Cells lacking the phosphatase CnrN (cnrN(-) cells) form small aggregation territories and few streams.1 In this report, we present computer simulations that suggest that in the absence of stream formation, CF should be unable to affect group size. As predicted, cnrN(-) group size is insensitive to the addition or depletion of CF. Together, the data indicate that CnrN regulates group size by regulating both the break-up of a field of cells into aggregation territories and stream formation during development, and that CnrN-mediated and CF-mediated group size regulation use different mechanisms.
Yitai Tang; Richard H Gomer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Communicative & integrative biology     Volume:  1     ISSN:  1942-0889     ISO Abbreviation:  Commun Integr Biol     Publication Date:  2008  
Date Detail:
Created Date:  2009-08-25     Completed Date:  2012-10-02     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101478473     Medline TA:  Commun Integr Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-7     Citation Subset:  -    
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