Document Detail


Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblasts.
MedLine Citation:
PMID:  21145745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Centrosomes comprise a pair of centrioles surrounded by an amorphous network of pericentriolar material (PCM). In certain stem cells, the two centrosomes differ in size, and this appears to be important for asymmetric cell division [1, 2]. In some cases, centrosome asymmetry is linked to centriole age because the older, mother centriole always organizes more PCM than the daughter centriole, thus ensuring that the mother centriole is always retained in the stem cell after cell division [3]. This has raised the possibility that an "immortal" mother centriole may help maintain stem cell fate [4, 5]. It is unclear, however, how centrosome size asymmetry is generated in stem cells. Here we provide compelling evidence that centrosome size asymmetry in Drosophila neuroblasts is generated by the differential regulation of Cnn incorporation into the PCM at mother and daughter centrioles. Shortly after centriole separation, mother and daughter centrioles organize similar amounts of PCM, but Cnn incorporation is then rapidly downregulated at the mother centriole, while it is maintained at the daughter centriole. This ensures that the daughter centriole maintains its PCM and so its position at the apical cortex. Thus, the daughter centriole, rather than an "immortal" mother centriole, is ultimately retained in these stem cells.
Authors:
Paul T Conduit; Jordan W Raff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-09
Journal Detail:
Title:  Current biology : CB     Volume:  20     ISSN:  1879-0445     ISO Abbreviation:  Curr. Biol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-21     Completed Date:  2011-04-04     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2187-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Centrioles / metabolism
Centrosome / metabolism
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster / cytology*,  embryology
Fluorescence Recovery After Photobleaching
Homeodomain Proteins / genetics,  metabolism*
Humans
Neurons / cytology*,  physiology
Recombinant Fusion Proteins / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
10530//Cancer Research UK; //Cancer Research UK
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Recombinant Fusion Proteins; 0/centrosomin protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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