Document Detail

Clustering of HBsAg in a family.
MedLine Citation:
PMID:  308017     Owner:  NLM     Status:  MEDLINE    
A study was performed on a family of 7 followed up over a 4-year period in which an outbreak of B-antigen-positive hepatitis occurred. Of the 5 male members who acquired HBsAg, 1 became a chronic asymptomatic carrier and 4 had episodes of acute icteric hepatitis during a 15-month period with development of histologically documented chronic hepatitis with persistent HBs antigenaemia in all. Of the 2 female members, 1 had an attack of acute HBsAg-positive hepatitis but recovered normally and cleared HBsAg from her serum, while the other was found to have anti-HBs with no evidence of liver disease. Serological and immunological studies carried out in all members of this family suggested that a sex-linked defect of T cell function itself could explain the differing host immune response to HBV infection in genetically related subjects.
G Pastore; G Fera; P Dentico; O Schiraldi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Digestion     Volume:  17     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1978  
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  428-36     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Carrier State
Child, Preschool
Chronic Disease
Hepatitis B / genetics*,  immunology
Hepatitis B Antigens*
Liver Function Tests
Lymphocyte Activation
T-Lymphocytes / immunology
Reg. No./Substance:
0/Hepatitis B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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