Document Detail


Clustered mixed nonhomogeneous Poisson process spline models for the analysis of recurrent event panel data.
MedLine Citation:
PMID:  18047528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A flexible semiparametric model for analyzing longitudinal panel count data arising from mixtures is presented. Panel count data refers here to count data on recurrent events collected as the number of events that have occurred within specific follow-up periods. The model assumes that the counts for each subject are generated by mixtures of nonhomogeneous Poisson processes with smooth intensity functions modeled with penalized splines. Time-dependent covariate effects are also incorporated into the process intensity using splines. Discrete mixtures of these nonhomogeneous Poisson process spline models extract functional information from underlying clusters representing hidden subpopulations. The motivating application is an experiment to test the effectiveness of pheromones in disrupting the mating pattern of the cherry bark tortrix moth. Mature moths arise from hidden, but distinct, subpopulations and monitoring the subpopulation responses was of interest. Within-cluster random effects are used to account for correlation structures and heterogeneity common to this type of data. An estimating equation approach to inference requiring only low moment assumptions is developed and the finite sample properties of the proposed estimating functions are investigated empirically by simulation.
Authors:
J D Nielsen; C B Dean
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-19
Journal Detail:
Title:  Biometrics     Volume:  64     ISSN:  1541-0420     ISO Abbreviation:  Biometrics     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-01-28     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  0370625     Medline TA:  Biometrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  751-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biometry / methods*
Cluster Analysis
Data Interpretation, Statistical
Female
Humans
Likelihood Functions
Longitudinal Studies
Male
Models, Statistical*
Moths / drug effects,  physiology
Poisson Distribution
Sex Attractants / pharmacology,  physiology
Grant Support
ID/Acronym/Agency:
R03 AG031113/AG/NIA NIH HHS; R03 AG031113-01A2/AG/NIA NIH HHS; R03 AG031113-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Sex Attractants
Comments/Corrections

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