| Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation. | |
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MedLine Citation:
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PMID: 11998870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Much of our understanding of the epidemiologic features of infection with Blastomyces dermatitidis has come from cluster and outbreak investigations which have established the association of human disease with recreational pursuits and the presence of infectious microfoci in areas of moist soil with high organic content. This report describes the clustering of eight cases of pulmonary blastomycosis without an apparent common source exposure which occurred during a 90 day period in a 96 square mile area (population 4,450) within Oconto County, Wisconsin. We conclude that multiple high-risk environmental foci may have existed following a sustained five-year period of diminished precipitation in the cluster area. A case-control study which included family and community controls concluded that multiple earth-disturbing activities engaged in by case-patients was statistically associated with illness. Lymphocyte-proliferation assays of whole blood samples detected previously unrecognized infection with B. dermatititidis among five of 32 family controls. |
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Authors:
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Mary E Proctor; Bruce S Klein; Jeffrey M Jones; Jeffrey P Davis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mycopathologia Volume: 153 ISSN: 0301-486X ISO Abbreviation: Mycopathologia Publication Date: 2002 |
Date Detail:
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Created Date: 2002-05-09 Completed Date: 2002-11-04 Revised Date: 2009-07-24 |
Medline Journal Info:
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Nlm Unique ID: 7505689 Medline TA: Mycopathologia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 113-20 Citation Subset: IM |
Affiliation:
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Wisconsin Department at Health and Family Servcices, Division of Public Health, Bureau of Communicable Diseases, Madison 53701, USA. proctme@dhfs.state.wi.us |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Antibodies, Fungal / analysis Blastomyces* / immunology Blastomycosis / epidemiology*, etiology, veterinary Case-Control Studies Child Child, Preschool Cluster Analysis Dog Diseases / epidemiology Dogs Female Fungal Proteins* Glycoproteins / immunology Humans Incidence Lung Diseases, Fungal / epidemiology*, microbiology, veterinary Lymphocyte Activation / immunology Male Middle Aged Rural Population Soil Microbiology Weather* Wisconsin / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Fungal; 0/Fungal Proteins; 0/Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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