Document Detail


Cluster differentiation-36 deficiency type 1 and acute coronary syndrome without major cardiovascular risk factors: case report.
MedLine Citation:
PMID:  17186996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 45-year-old man without major coronary risk factors, including hypertension, diabetes mellitus, smoking, hypercholesterolemia, hyperuricemia, or a family history of early cardiovascular disease, presented with acute coronary syndrome. Angiography showed thrombus formation in segment 7 of the left anterior descending coronary artery, and percutaneous coronary intervention was successful after implantation of a bare metal stent. Scintigraphy showed the absence of 123I-beta-methyl-iodophenyl pentadecanoic acid accumulation in the myocardium. Flow cytometric analysis of platelets and monocytes showed the absence of cluster differentiation (CD)-36 expression. These findings are consistent with a diagnosis of CD36 deficiency type 1, which might be associated with cardiovascular disease. The patient had no apparent major coronary risk factors except for insulin resistance and an abnormal lipoprotein profile. The findings suggest that in this case the CD36 deficiency type 1 was the pathogenic mechanism of acute coronary syndrome relative to insulin resistance and modification of the lipid profile.
Authors:
Tomohiko Yasunaga; Seiji Koga; Satoshi Ikeda; Chie Yasuoka; Yasuo Sonoda; Yoshito Tanioka; Shigeru Kohno
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Affiliation:
Cardiovascular Center, Omura Municipal Hospital, Second Department of Internal Medicine, School of Medicine, Nagasaki University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD36 / genetics*,  metabolism
Coronary Angiography
Coronary Thrombosis / etiology*,  genetics*,  metabolism
Electrocardiography
Gene Expression Regulation
Humans
Insulin Resistance
Male
Middle Aged
Risk Factors
Chemical
Reg. No./Substance:
0/Antigens, CD36

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