Document Detail

Cluster analysis to classify gait alterations in rheumatoid arthritis using peak pressure curves.
MedLine Citation:
PMID:  18815041     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To detect gait alterations in rheumatoid arthritis (RA) patients using peak pressure curves (PPC) and normalized force curves (NFC) instead of clinical classification based on the health assessment questionnaire (HAQ). METHODS: Three RA groups--30 patients each--were classified according to their HAQ score. Cluster analysis based on a k-means algorithm was applied to PPCs and NFCs in order to classify RA patients with respect to amplitude and shapes of such gait parameters. RESULTS: The best gait pattern identification was obtained by clustering PPCs into three clusters. Peak pressures of the three identified patterns were 1169.5+/-99.4 kPa for cluster 1, 885.8+/-165.2 kPa for cluster 2 and 402.0+/-128.5 kPa for cluster 3 (statistically different, Student's t-test, p<0.001). 41 patients were included in cluster 3, 31 in cluster 2 and only 18 patients in cluster 1. Most RA3 patients--17 out of 30--showed low peak pressures and almost normal PPCs (cluster 3). Cluster 2, which incorporated altered PPCs, was mainly formed by RA1 and RA2 patients. CONCLUSIONS: PPC appears as a reliable gait parameter for a shape-based clustering algorithm. The proposed cluster analysis was proved to be reliable and the delivered classifications stable. The distribution of RA patients among the three identified PPC clusters showed only a partial agreement between clinical and functional classification, thus revealing the development of specific gait strategies related to the pathology more than to its clinical level of severity. This finding may be clinically relevant and support effective treatment of RA gait related pathologies.
Claudia Giacomozzi; Francesco Martelli; Arne Nagel; Andreas Schmiegel; Dieter Rosenbaum
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-23
Journal Detail:
Title:  Gait & posture     Volume:  29     ISSN:  1879-2219     ISO Abbreviation:  Gait Posture     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9416830     Medline TA:  Gait Posture     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Department of Technology and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
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MeSH Terms
Arthritis, Rheumatoid / physiopathology*
Cluster Analysis
Foot / physiopathology*
Forefoot, Human / physiopathology
Gait* / physiology
Health Status
Middle Aged
Multivariate Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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