Document Detail

Cluster of Urrets-Zavalia syndrome: a sequel of toxic anterior segment syndrome.
MedLine Citation:
PMID:  23410729     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report the largest cluster of Urrets-Zavalia Syndrome (UZS), which occurred as a sequel of toxic anterior segment syndrome (TASS) after uneventful cataract surgery, and to evaluate the possible causes and risk factors to prevent additional cases.
SETTING: Department of Ophthalmology, Liaquat University of Medical & Health Sciences, Hyderabad, Pakistan.
DESIGN: Prospective Case Series.
METHODS: 15 consecutive TASS cases following uneventful cataract surgery were evaluated for potential causes and risk factors. Main outcome measures included visual acuity, anterior segment reaction, corneal oedema, intraocular pressure, pupillary reaction and response to topical and/or systemic steroid therapy at first day, first week and first month postoperatively.
RESULTS: The TASS incidence in this study was 0.08%. All cases presented with corneal oedema, anterior chamber reaction and fixed dilated pupils on first postoperative day. One month postoperatively, the anterior segment inflammation improved considerably in all patients. There was a statistically significant difference between the mean Best-corrected visual acuity (BCVA) at first postoperative day (2.32±0.93 LogMAR) and mean BCVA at 1 month (0.49±0.12 LogMAR) (p=0.0001). The rate of UZS in this study was 93%. Ringer lactate solution was found to be the offending agent of TASS, and replacing it brought a halt to this cluster.
CONCLUSIONS: Timely diagnosis, steroid therapy and close monitoring are the main keys for properly managing TASS. To our knowledge, we report, for the first time, the largest cluster of UZS occurring as a sequel of TASS.
Noor Bakht Nizamani; Imran Ahmed Bhutto; Khalid Iqbal Talpur
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Publication Detail:
Type:  Journal Article     Date:  2013-02-14
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  97     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-11     Completed Date:  2013-10-17     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  976-9     Citation Subset:  IM    
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MeSH Terms
Anterior Eye Segment / pathology*
Cataract Extraction
Cluster Analysis
Corneal Edema / diagnosis
Endophthalmitis / epidemiology*
Lens Implantation, Intraocular
Pakistan / epidemiology
Postoperative Complications*
Prospective Studies
Pupil Disorders / etiology*
Risk Factors
Uveitis, Anterior / epidemiology*
Comment In:
Br J Ophthalmol. 2013 Aug;97(8):953   [PMID:  23843478 ]
Br J Ophthalmol. 2014 Mar;98(3):414   [PMID:  24288391 ]
Br J Ophthalmol. 2013 Dec;97(12):1612   [PMID:  24081503 ]

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