Document Detail


Cluster of Malassezia furfur pulmonary infections in infants in a neonatal intensive-care unit.
MedLine Citation:
PMID:  2753995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Between 23 and 27 July 1987, three infants at one hospital developed severe bronchopneumonia associated with respiratory failure, thrombocytopenia, and leukocytosis. Two infants died; at postmortem examination, Malassezia furfur was identified in their lung tissues. M. furfur was isolated from cultures of blood, urine, and stool samples from the infant who survived. All documented M. furfur infections occurred in infants with a birth weight of less than 1,000 g; the attack rate was 42.9% (three of seven infants). A case-control study comparing the three cases and nine infants randomly selected from infants in the neonatal intensive care unit during the outbreak showed the following variables to be significantly associated with case-infants: younger gestational age (less than 26 weeks), hyaline membrane disease, duration of ventilation, duration of antimicrobial therapy, and the presence of a Broviac catheter. In a second case-control study, in which case-infants were compared with birth weight-matched controls, only the duration of antimicrobial therapy was significantly associated with case-infants. A point prevalence culture survey showed that 2 of 10 infants and 2 of 11 personnel were colonized with M. furfur. This cluster suggests that M. furfur can be transmitted from an infected or colonized infant to other infants. Infection control practices should be aimed at (i) identifying high-risk infants and (ii) reemphasizing the importance of hand washing.
Authors:
H M Richet; M M McNeil; M C Edwards; W R Jarvis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  27     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1197-200     Citation Subset:  IM    
Affiliation:
Hospital Infections Program, Centers for Disease Control, Atlanta, Georgia 30333.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Catheterization, Central Venous
Cross Infection / epidemiology*,  etiology
Disease Outbreaks*
Female
Gestational Age
Humans
Hyaline Membrane Disease / complications
Infant, Newborn
Intensive Care Units, Neonatal*
Lung / microbiology
Lung Diseases, Fungal / epidemiology*,  etiology
Malassezia / isolation & purification
Male
Respiration, Artificial
Risk Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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