Document Detail


Clues from bariatric surgery: reversing insulin resistance to heal the heart.
MedLine Citation:
PMID:  23354680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectively addresses the evidence for this phenomenon in the literature and discusses potential metabolic and neurohumoral mechanisms. We propose that nutrient restriction lowers the cell's defense mechanisms for nutrient overload in insulin responsive organs.
Authors:
Khaled Imad Khalaf; Heinrich Taegtmeyer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current diabetes reports     Volume:  13     ISSN:  1539-0829     ISO Abbreviation:  Curr. Diab. Rep.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-09-04     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101093791     Medline TA:  Curr Diab Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bariatric Surgery*
Diabetes Mellitus, Type 2 / metabolism,  surgery
Humans
Insulin Resistance / physiology*
Obesity / metabolism,  surgery
Grant Support
ID/Acronym/Agency:
5R01HL061483/HL/NHLBI NIH HHS; 5R01HL073162/HL/NHLBI NIH HHS; R01 HL061483/HL/NHLBI NIH HHS; R01 HL073162/HL/NHLBI NIH HHS
Comments/Corrections

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