Document Detail

Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients.
MedLine Citation:
PMID:  20101184     Owner:  NLM     Status:  MEDLINE    
Eight schizophrenic inpatients without manifest comorbidity were longitudinally studied. The aim was to find whether clozapine, the prototype of atypical antipsychotic drugs, altered their serum concentrations of high sensitive C-reactive protein (hsCRP), an inflammatory marker of high clinical importance. Following first-time therapy with clozapine, predominantly as the sole antipsychotic for 8 weeks, hsCRP profiles increased subclinically by 600%. This rise, and the Spearman correlation between hsCRP values and corresponding leukocyte counts, was statistically significant. A one-time cross-section investigation of 25 long-term clozapine patients and 25 patient controls did not show an elevation of hsCRP under clozapine after 1 year and more. It is assumed that the clozapine-evoked increase of hsCRP is part of a transient acute-phase response. The underlying inflammatory process needs clarification.
Stefan L?ffler; Mignon L?ffler-Ensgraber; Karin Fehsel; Ansgar Klimke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  25     ISSN:  1473-5857     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-05     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, Klinikum Offenbach GmbH, Mainz, Germany.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use*
C-Reactive Protein / metabolism*
Clozapine / adverse effects*,  therapeutic use*
Cross-Sectional Studies
Longitudinal Studies
Middle Aged
Psychiatric Status Rating Scales
Schizophrenia / blood*,  drug therapy*
Schizophrenic Psychology
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine; 9007-41-4/C-Reactive Protein

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