Document Detail


Clozapine and tardive movement disorders: A review.
MedLine Citation:
PMID:  24309853     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Tardive syndromes (TS) arise from long term exposure to dopamine receptor blocking agents. Clozapine has been considered to have low risk of causing new onset TS and is considered as a treatment option in patients with TS.
AIM: This review evaluates the usefulness of clozapine in patients with TS and occasional reports of clozapine causing TS.
METHODOLOGY: Electronic searches were carried out using the search engines of PUBMED, Science direct and Google Scholar databases. All reports describing use of clozapine in management of TS, monitoring of TS while on clozapine and onset of TS after initiation of clozapine were identified.
RESULTS: Fifteen trials and 28 case series/case reports describe the use of clozapine in TS. Most of these reports show that clozapine is useful in patients with TS, in the dose range of 200-300mg/day and the beneficial effect is seen within 4-12 weeks of initiation. One case series and two case reports described clozapine withdrawal emergent dyskinesias suggesting a masking role of clozapine. One trial, three case series and two case reports describe beneficial effects of clozapine on long standing neurological syndromes. There is relatively less literature (2 trials and 15 case series/reports) describing the emergence of TS with clozapine.
CONCLUSION: Evidence of beneficial effects of clozapine in TS is greater than its role in causation/worsening of TS. Hence, clozapine should be considered in symptomatic patients who develop TS while receiving other antipsychotics. Further research on mechanism of TS and clozapine effect on TS is required.
Authors:
Nandita Hazari; Natasha Kate; Sandeep Grover
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Publication Detail:
Type:  Journal Article     Date:  2013-08-22
Journal Detail:
Title:  Asian journal of psychiatry     Volume:  6     ISSN:  1876-2026     ISO Abbreviation:  Asian J Psychiatr     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517820     Medline TA:  Asian J Psychiatr     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  439-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
Affiliation:
Department of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
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