| Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment. | |
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MedLine Citation:
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PMID: 17879354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An exemplary case report of a patient who developed an unpredictable sudden, late-onset clozapine-related life-threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/microL, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature. |
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Authors:
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Roberto Manfredi; Sergio Sabbatani |
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Publication Detail:
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Type: Case Reports |
Journal Detail:
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Title: Pharmacoepidemiology and drug safety Volume: 16 ISSN: 1053-8569 ISO Abbreviation: Pharmacoepidemiol Drug Saf Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208369 Medline TA: Pharmacoepidemiol Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 1285-9 Citation Subset: IM |
Copyright Information:
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Copyright 2007 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. Roberto.manfredi@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Agranulocytosis / chemically induced*, complications Anti-Infective Agents / therapeutic use* Antipsychotic Agents / adverse effects, therapeutic use Clozapine / adverse effects*, therapeutic use Fever of Unknown Origin / chemically induced*, complications Hospitalization* Humans Leukocyte Count Male |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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