Document Detail

Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment.
MedLine Citation:
PMID:  17879354     Owner:  NLM     Status:  MEDLINE    
An exemplary case report of a patient who developed an unpredictable sudden, late-onset clozapine-related life-threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/microL, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature.
Roberto Manfredi; Sergio Sabbatani
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Publication Detail:
Type:  Case Reports    
Journal Detail:
Title:  Pharmacoepidemiology and drug safety     Volume:  16     ISSN:  1053-8569     ISO Abbreviation:  Pharmacoepidemiol Drug Saf     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208369     Medline TA:  Pharmacoepidemiol Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  1285-9     Citation Subset:  IM    
Copyright Information:
Copyright 2007 John Wiley & Sons, Ltd.
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
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MeSH Terms
Agranulocytosis / chemically induced*,  complications
Anti-Infective Agents / therapeutic use*
Antipsychotic Agents / adverse effects,  therapeutic use
Clozapine / adverse effects*,  therapeutic use
Fever of Unknown Origin / chemically induced*,  complications
Leukocyte Count
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antipsychotic Agents; 5786-21-0/Clozapine

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