| Clozapine-induced serositis: review of its clinical features, pathophysiology and management strategies. | |
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MedLine Citation:
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PMID: 19620851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the benefits of clozapine have been well demonstrated in resistant schizophrenia, the frequency of adverse events is of particular concern: up to 76% of patients to whom clozapine was prescribed experienced an adverse event, with a discontinuation rate of 17%. In addition to its major clinical side effect, agranulocytosis, clozapine is reported to induce inflammatory syndromes with polyserositis. Apart from sparse case reports, no study has yet addressed this particularly interesting issue. With the aim of improving the outcome of clozapine-treated patients, we undertook a review of the literature to characterize the clinical features of clozapine-induced serositis, its pathophysiology, and to propose strategies of clinical management. |
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Authors:
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Fayçal Mouaffak; Raphael Gaillard; Elizabeth Burgess; Hanane Zaki; Jean Pierre Olié; Marie-Odile Krebs |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 32 ISSN: 1537-162X ISO Abbreviation: Clin Neuropharmacol Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-07-31 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 219-23 Citation Subset: IM |
Affiliation:
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Center of Psychiatry and Neurosciences, INSERM U894. mouaffakf@yahoo.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects* Clozapine / adverse effects* Female Humans Male Schizophrenia / drug therapy*, physiopathology Serositis / chemically induced*, physiopathology, therapy Withholding Treatment |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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