| Clozapine-induced neuroleptic malignant syndrome: review and report of new cases. | |
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MedLine Citation:
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PMID: 8830069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The published case reports of clozapine-induced neuroleptic malignant syndrome (NMS) are reviewed, to which the authors add three, and possibly four, new cases seen in Australia, occurring in and estimated 1,250 patients exposed to the drug. The review suggests that typical NMS does occur with clozapine and that its incidence may be as common as with the classic neuroleptics. The features of clozapine-induced NMS may be somewhat different, with fewer extrapyramidal side effects and a lower rise in creatine kinase levels. The occurrence of NMS with clozapine raises important issues with regard to our understanding of the pathophysiology of the syndrome. |
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Authors:
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P Sachdev; J Kruk; M Kneebone; D Kissane |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 15 ISSN: 0271-0749 ISO Abbreviation: J Clin Psychopharmacol Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1996-10-16 Completed Date: 1996-10-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 365-71 Citation Subset: IM |
Affiliation:
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Neuropsychiatric Institute, Prince Henry Hospital, Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antipsychotic Agents / adverse effects*, therapeutic use Australia Child Clozapine / adverse effects*, therapeutic use Creatine Kinase / blood Female Humans Male Middle Aged Neuroleptic Malignant Syndrome / etiology* Neurologic Examination / drug effects Schizophrenia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 5786-21-0/Clozapine; EC 2.7.3.2/Creatine Kinase |
| Comments/Corrections | |
Comment In:
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J Clin Psychopharmacol. 1997 Jun;17(3):233-4
[PMID:
9169977
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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