Document Detail

Clozapine-induced neuroleptic malignant syndrome: review and report of new cases.
MedLine Citation:
PMID:  8830069     Owner:  NLM     Status:  MEDLINE    
The published case reports of clozapine-induced neuroleptic malignant syndrome (NMS) are reviewed, to which the authors add three, and possibly four, new cases seen in Australia, occurring in and estimated 1,250 patients exposed to the drug. The review suggests that typical NMS does occur with clozapine and that its incidence may be as common as with the classic neuroleptics. The features of clozapine-induced NMS may be somewhat different, with fewer extrapyramidal side effects and a lower rise in creatine kinase levels. The occurrence of NMS with clozapine raises important issues with regard to our understanding of the pathophysiology of the syndrome.
P Sachdev; J Kruk; M Kneebone; D Kissane
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  15     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-10-16     Completed Date:  1996-10-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-71     Citation Subset:  IM    
Neuropsychiatric Institute, Prince Henry Hospital, Sydney, Australia.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Clozapine / adverse effects*,  therapeutic use
Creatine Kinase / blood
Middle Aged
Neuroleptic Malignant Syndrome / etiology*
Neurologic Examination / drug effects
Schizophrenia / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine; EC Kinase
Comment In:
J Clin Psychopharmacol. 1997 Jun;17(3):233-4   [PMID:  9169977 ]

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