Document Detail

Clozapine-induced elevated C-reactive protein and fever mimic infection.
MedLine Citation:
PMID:  24199788     Owner:  NLM     Status:  In-Data-Review    
Clozapine-induced fever has been reported frequently, but clozapine-induced elevated serum C-reactive protein (S-CRP) over 100 mg/L with early onset, without associated myocarditis, has not been reported in the literature. In this case report, we present a case of an 80-year-old Slovenian female with dementia and psychotic symptoms who developed elevated S-CRP (122 mg/L) and fever (38.2°C) on the seventh day with 25 mg of clozapine daily, which improved after clozapine discontinuation. The patient did not have symptoms and signs of infection. This case report can be used to remind clinicians of keeping in mind the potential of clozapine associated with very high elevated S-CRP with fever, which can be easily confused with more serious conditions.
Matej Stuhec
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Publication Detail:
Type:  Journal Article     Date:  2013-04-28
Journal Detail:
Title:  General hospital psychiatry     Volume:  35     ISSN:  1873-7714     ISO Abbreviation:  Gen Hosp Psychiatry     Publication Date:    2013 Nov-Dec
Date Detail:
Created Date:  2013-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905527     Medline TA:  Gen Hosp Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680.e5-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Ormoz Psychiatric Hospital, Department of Clinical Pharmacy, Slovenia, Ptujska Cesta 33, Ormoz, Slovenia. Electronic address:
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