Document Detail


Clozapine chronically suppresses alcohol drinking in Syrian golden hamsters.
MedLine Citation:
PMID:  19895824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol use disorder is common in patients with schizophrenia and is associated with poor clinical outcomes. Preliminary reports from our group and others suggest that the atypical antipsychotic clozapine may decrease alcohol use in these patients. We have previously shown that clozapine suppresses alcohol consumption for 9 days in Syrian golden hamsters. Here, we assessed the effects of clozapine on alcohol consumption in hamsters over a 27-day period, using a continuous access, 2-bottle (15% alcohol vs. water) protocol. Clozapine (4, 8, or 12 mg/kg/day, injected subcutaneously [s.c.]) dose-dependently suppressed alcohol drinking, while increasing food and water intake. There was no tolerance within individual groups to the effect of clozapine on alcohol drinking over time. In a separate experiment, the effects of clozapine on sucrose and water drinking and food intake over a 9-day period were assessed. Clozapine (4, 8, or 12 mg/kg/day s.c.) failed to suppress sucrose (0.09 M), food, or water consumption at any time-point tested. In a related study, assessment of blood alcohol levels in hamsters indicated that blood alcohol levels were maintained within a narrow and moderate range (7-13 mg/dL), levels noted by others to produce physiologic effects in rodents. The ability of clozapine to suppress alcohol drinking in the hamster over an extended period of time without suppressing sucrose, water, or food consumption is consistent with preliminary reports indicating that clozapine limits frequent alcohol use, even producing abstinence in many patients with schizophrenia.
Authors:
David T Chau; Danielle Gulick; Haiyi Xie; Ree Dawson; Alan I Green
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-11-04
Journal Detail:
Title:  Neuropharmacology     Volume:  58     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Copyright Information:
2009. Published by Elsevier Ltd.
Affiliation:
Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / blood,  drug therapy*
Animals
Antipsychotic Agents / administration & dosage,  pharmacology
Clozapine / administration & dosage,  pharmacology*
Cricetinae
Dietary Sucrose / administration & dosage
Dose-Response Relationship, Drug
Drinking Behavior / drug effects
Ethanol / administration & dosage,  blood
Feeding Behavior / drug effects
Male
Mesocricetus
Psychotropic Drugs / administration & dosage,  pharmacology*
Random Allocation
Time Factors
Water / administration & dosage
Grant Support
ID/Acronym/Agency:
1R03AA014644/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dietary Sucrose; 0/Psychotropic Drugs; 5786-21-0/Clozapine; 64-17-5/Ethanol; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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