Document Detail

Clozapine (Clozaril), seizures, and EEG abnormalities.
MedLine Citation:
PMID:  17982847     Owner:  NLM     Status:  MEDLINE    
The antipsychotic agent clozapine (ClozarilE) is reserved for the treatment of refractory psychosis. Clozapine has allowed many schizophrenic patients to lead more independent and productive lives, but its use is restricted by side effects. Clozapine has been shown to lower seizure threshold and produce significant EEG changes. Although not a commonly used drug, both clinical neurophysiology technologists and interpreting electroencephalographers need to be aware of the effects of clozapine on the EEG. We review the findings of two patients who developed neurological symptoms and EEG abnormalities that resolved following reduction of clozapine therapy.
Diane M White; Anne C Van Cott
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of electroneurodiagnostic technology     Volume:  47     ISSN:  1086-508X     ISO Abbreviation:  Am J Electroneurodiagnostic Technol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607038     Medline TA:  Am J Electroneurodiagnostic Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-7     Citation Subset:  IM    
Veterans Administration Pittsburgh Healthcare System Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Antipsychotic Agents / administration & dosage
Clozapine / administration & dosage*
Electroencephalography / drug effects*,  methods*
Middle Aged
Seizures / diagnosis*,  drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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