Document Detail

Clove (Syzygium aromaticum Linn) extract rich in eugenol and eugenol derivatives shows bone-preserving efficacy.
MedLine Citation:
PMID:  21711176     Owner:  NLM     Status:  MEDLINE    
This study examined the efficacy of hydroalcoholic extract of dried clove buds, which is rich in phenolic compounds namely eugenol and eugenol derivatives (precursors of flavones, isoflavones and flavonoids), on different primary and secondary osteoporotic marker changes in an ovariectomised (OVX) rat model of osteoporosis. Female Wistar rats were randomly divided into three groups: sham-operated control (A), OVX (B) and OVX plus 50% hydroalcoholic extract of dried clove buds for 4 weeks (C). Results indicated that, compared to control, serum alkaline phosphatase (AP; 48.25%, p < 0.01), serum tartrate-resistant acid phosphatase (TRAP; 63.48%, p < 0.01), urinary calcium (14.70%, p < 0.01), urinary phosphate (50.30%, p < 0.01) and urinary creatinine (122.44%, p < 0.01) were significantly altered in OVX rats. All these altered responses were significantly restored (AP: 27.53%, p < 0.01; TRAP: 33.51%, p < 0.01; calcium: 53.15%, p < 0.01; phosphate: 27.49%, p < 0.01; creatinine: 46.40%, p < 0.01) by supplementation with hydroalcoholic extract of dried clove buds. Results of bone density, bone mineral content, bone tensile strength and histological analysis also showed similar trend of results, which supported initial observations of this study. It is proposed that hydroalcoholic extract of dried clove buds has bone-preserving efficacy against hypogonadal osteoporosis.
Subhra Karmakar; Monalisa Choudhury; Asankur Sekhar Das; Anasuya Maiti; Sangita Majumdar; Chandan Mitra
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Publication Detail:
Type:  Journal Article     Date:  2011-06-28
Journal Detail:
Title:  Natural product research     Volume:  26     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-13     Completed Date:  2012-06-06     Revised Date:  2012-06-07    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  500-9     Citation Subset:  IM    
Pre-Clinical Physiology Laboratory, Tripura Institute of Paramedical Sciences, Hapania, Tripura (West), India.
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MeSH Terms
Acid Phosphatase / blood
Alkaline Phosphatase / blood
Bone Density / drug effects
Calcium / deficiency,  urine
Clove Oil / pharmacology,  therapeutic use*
Creatinine / urine
Disease Models, Animal
Drug Evaluation, Preclinical
Eugenol / analogs & derivatives,  pharmacology,  therapeutic use
Isoenzymes / blood
Osteoporosis / prevention & control*
Phosphates / urine
Rats, Wistar
Tensile Strength / drug effects
Tibia / drug effects
Reg. No./Substance:
0/Clove Oil; 0/Isoenzymes; 0/Phosphates; 60-27-5/Creatinine; 7440-70-2/Calcium; 97-53-0/Eugenol; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC Phosphatase; EC Phosphatase

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