Document Detail


Clot lysis time and thrombin activatable fibrinolysis inhibitor in severe preeclampsia with or without associated antiphospholipid antibodies.
MedLine Citation:
PMID:  20594598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated clot lysis time, thrombin activatable fibrinolysis inhibitor antigen (TAFI) levels and TAFI gene polymorphisms in pregnant patients with severe preeclampsia, with or without associated antiphospholipid syndrome (APS). The study groups included 82 pregnant patients without antiphospholipid antibodies with severe preeclampsia (PE group) and 10 pregnant APS patients who developed severe preeclampsia (APS-PE group). Controls included 76 primary pregnant APS patients (APS group) and 89 healthy pregnant patients (NOR group) with uneventful term pregnancy and delivery. Patients in the APS-PE, APS and NOR groups were sampled during each trimester of pregnancy and at 4-6 months and 12 months after delivery. Patients in the PE group were sampled during the third trimester and after delivery. Significantly prolonged clot lysis time after delivery was found in the PE, APS-PE and APS groups compared to the NOR group. The PE and APS-PE groups had longer clot lysis time than the APS group. Levels of TAFI were found to be higher after delivery in patients of the PE and APS-PE groups compared to the APS and NOR groups. Allele distribution of the TAFI gene polymorphisms was similar among the four study groups. We conclude that increased TAFI antigen levels and impaired fibrinolysis are pathogenetic factors in preeclampsia, regardless of whether or not preeclampsia is associated with the presence of antiphospholipid antibodies.
Authors:
M Angeles Martínez-Zamora; Dolors Tassies; Francisco Carmona; Gerard Espinosa; Ricard Cervera; Juan Carlos Reverter; Juan Balasch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-01
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  86     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, University of Barcelona, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Antibodies, Antiphospholipid / blood*
Antiphospholipid Syndrome / blood*,  complications,  genetics
Blood Coagulation Tests
Carboxypeptidase U / blood*,  genetics
Female
Fibrinolysis
Humans
Polymorphism, Genetic
Postpartum Period / blood*,  genetics
Pre-Eclampsia / blood*,  genetics
Pregnancy
Pregnancy Trimesters / blood*,  genetics
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; EC 3.4.17.20/Carboxypeptidase U

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