Document Detail


Clot fragments formed from original thrombus obstruct downstream arteries in the ischemic injured brain.
MedLine Citation:
PMID:  16627365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Embolic occlusion of the middle cerebral artery (MCA) leads to distal perfusion deficits as the vessel is recanalized. However, the mechanism for the perfusion deficits is not fully understood. The authors examined whether distal movement of fragments formed from the original thrombus contributes to the perfusion deficits. METHODS: In the first series, they studied whether the reduction in perfusion deficits is due to the dissolution of the original clots embolized or due to collateral perfusion. In the second series, they studied whether fragments formed from the original clots move to distal arterial system. In the third series, they studied whether plasminogen activator plays a role in the thrombolysis following ischemia. RESULTS: Occlusion of MCA permanently resulted in large perfusion deficits in the ipsilateral hemisphere, and these perfusion deficits did not change significantly after the occlusion. In contrast, perfusion deficits reduced significantly in a model of transient MCA occlusion. The numbers of fragments formed from the original clots increased gradually after the MCA occlusion in the ischemic injured brain. In addition, expression of urokinase plasminogen activator was also upregulated. CONCLUSION: The present study thus reveals the mechanisms of the downstream arterial occlusion following the dissolution of original thrombus.
Authors:
Chen Xu Wang; Tao Yang; Ashfaq Shuaib
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  13     ISSN:  1073-9688     ISO Abbreviation:  Microcirculation     Publication Date:    2006 Apr-May
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-07-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Affiliation:
Stroke Research Laboratory, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / etiology*
Blood Coagulation
Brain Ischemia / etiology*
Disease Models, Animal
Embolism / etiology*
Male
Middle Cerebral Artery / pathology
Rats
Rats, Sprague-Dawley
Thrombosis / complications*
Up-Regulation / genetics
Urokinase-Type Plasminogen Activator / genetics
Chemical
Reg. No./Substance:
EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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