Document Detail

Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis.
MedLine Citation:
PMID:  950959     Owner:  NLM     Status:  MEDLINE    
Inhibition of prostaglandin synthesis constricts the ductus arteriosus in fetal lambs in utero. We administered the inhibitors, aspirin or indomethacin to 18 premature infants with patent ductus arteriosus, and assessed the effects clinically and by echocardiography (left atrial/aortic-root ratio). After aspirin (20 mg per kilogram, every six hours for four doses) the ductus closed permanently in one infant within 24 hours; in another, constriction occurred with clinical improvement, and the third did not respond. In five infants given 0.3 mg per kilogram of indomethacin, complete closure occurred within one day; two of them, who received three doses had an elevated serum creatinine for one week. In one infant the ductus reopened, requiring a second dose of indomethacin 11 days after the first. Ten infants received 0.1 mg per kilogram of indomethacin, and closure occurred within 24 to 30 hours in eight. One had a soft murmur for four days, and one did not respond to two doses of indomethacin. A murmur reappeared after three to seven days in three infants but only one required further treatment. In infants receiving a single dose of 0.3 mg per kilogram, or one or more doses of 0.1 mg per kilogram, renal function was unaltered.
M A Heymann; A M Rudolph; N H Silverman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  295     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  530-3     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / pharmacology,  therapeutic use*
Depression, Chemical
Ductus Arteriosus / drug effects
Ductus Arteriosus, Patent / drug therapy*
Follow-Up Studies
Indomethacin / administration & dosage,  pharmacology,  therapeutic use*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Prostaglandins / biosynthesis*
Reg. No./Substance:
0/Prostaglandins; 50-78-2/Aspirin; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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