Document Detail


Closure of atrial septal defects with the Amplatzer occlusion device: preliminary results.
MedLine Citation:
PMID:  9562015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study reports our clinical experience with transcatheter closure of secundum atrial septal defects (ASDs) in children, using the Amplatzer, a new occlusion device. BACKGROUND: None of the devices previously used for transcatheter closure of interatrial communications has gained wide acceptance. METHODS: We examined the efficacy and safety of the Amplatzer, a new self-centering septal occluder that consists of two round disks made of Nitinol wire mesh and linked together by a short connecting waist. Sixteen patients with secundum ASD met established two- and three-dimensional echocardiographic and cardiac catheterization criteria for transcatheter closure. The Amplatzer's size was chosen to be equal to or 1 mm less than the stretched diameter. The device was advanced transvenously into a 7F long guiding sheath and deployed under fluoroscopic and ultrasound guidance. Once its position was optimal, it was released. RESULTS: The mean ASD diameter by transesophageal echocardiography was 14.1+/-2.3 mm and was significantly smaller (p < 0.001) than the stretched diameter of the ASD (16.8+/-2.4 mm). The mean device diameter was 16.6+/-2.3 mm. No complications were observed. After deployment of the prosthesis, there was no residual shunt in 13 (81.3%) of 16 patients. In three patients there was trivial residual shunt immediately after the procedure that had disappeared in two of them at the 3-month follow-up. CONCLUSIONS: The Amplatzer is an efficient prosthesis that can be safely applied in children with secundum ASD. However, a study including a large number of patients and a longer follow-up period are required before this technique can be widely used.
Authors:
B D Thanopoulos; C V Laskari; G S Tsaousis; A Zarayelyan; A Vekiou; G S Papadopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  31     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-07     Completed Date:  1998-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1110-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Echocardiography, Doppler, Color
Heart Catheterization
Heart Septal Defects, Atrial / surgery*,  ultrasonography
Humans
Prostheses and Implants*
Prosthesis Design
Prosthesis Implantation / methods
Treatment Outcome
Comments/Corrections
Comment In:
J Am Coll Cardiol. 1998 Apr;31(5):1117-9   [PMID:  9562016 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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