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Clostridium difficile outbreaks: prevention and treatment strategies.
MedLine Citation:
PMID:  22826646     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The incidence and severity of Clostridium difficile infection (CDI) have increased dramatically over the past decade. Its treatment, however, has largely remained the same with the exception of oral vancomycin use as a first-line agent in severe disease. From 1999 to 2004, 20,642 deaths were attributed to CDI in the United States, almost 7 times the rate of all other intestinal infections combined. Worldwide, several major CDI outbreaks have occurred, and many of these were associated with the NAP1 strain. This 'epidemic' strain has contributed to the rising incidence and mortality of CDI. The purpose of this article is to review the current management, treatment, infection control, and prevention strategies that are needed to combat this increasingly morbid disease.
Authors:
Fernando J Martinez; Daniel A Leffler; Ciaran P Kelly
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Publication Detail:
Type:  Journal Article     Date:  2012-07-03
Journal Detail:
Title:  Risk management and healthcare policy     Volume:  5     ISSN:  1179-1594     ISO Abbreviation:  Risk Manag Healthc Policy     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-24     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101566264     Medline TA:  Risk Manag Healthc Policy     Country:  England    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  -    
Affiliation:
Division of Gastroenterology, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA.
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