Document Detail

Clostridium difficile in haematological malignancy.
MedLine Citation:
PMID:  3857233     Owner:  NLM     Status:  MEDLINE    
Twenty patients with haematological malignancies who developed Clostridium difficile bowel infection or colonisation are described. All isolates of C difficile were toxigenic in vitro and faecal cytotoxin (toxin B) was detected in 20/26 episodes. Ten of 20 episodes with detectable faecal cytotoxin were associated with typical antibiotic associated diarrhoea. In the other 10 episodes (nine patients), there was a severe unusual illness which was associated with detection of C difficile. The unusual features of the illness were pronounced jaundice (total bilirubin greater than or equal to 44 mumol/l), abdominal pain and distension, and initial constipation followed either by diarrhoea or by large bowel stasis. Four of these patients died within seven days. Bacteraemia was often a presenting feature in neutropenic patients subsequently shown to have C difficile. This was not the case in non-neutropenic patients. Bacteraemia was commonly polymicrobial and in two cases C difficile was isolated from blood culture. The clinical implications of recognition of this atypical C difficile associated syndrome are discussed.
A Rampling; R E Warren; P C Bevan; C E Hoggarth; D Swirsky; F G Hayhoe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  38     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-11     Completed Date:  1985-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  AIM; IM    
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MeSH Terms
Clostridium / isolation & purification
Clostridium Infections / complications*
Cytotoxins / analysis
Diarrhea / complications
Feces / microbiology
Leukemia / complications*
Leukemia, Lymphoid / complications,  microbiology
Leukemia, Myeloid, Acute / complications,  microbiology
Middle Aged
Neutropenia / complications
Sepsis / complications
Reg. No./Substance:

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