| Clostridium difficile-associated diarrhea and colitis in adults. A prospective case-controlled epidemiologic study. | |
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MedLine Citation:
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PMID: 3942469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a one-year period, 149 adult cases of Clostridium difficile-associated diarrhea and colitis were compared with 148 diarrhea-free controls. Eighty-seven percent were nosocomial and 75% were on surgical services. Endoscopy revealed pseudomembranes in 51% of the 109 cases in which stool cytotoxin was present, compared with 11% of the 40 cases that were culture-positive but cytotoxin-negative. Cases diagnosed only by stool culture showed essentially no differences from controls, 21% of whom had asymptomatic stool colonization. We estimate that only 20% of these cases had diarrhea due to C difficile. Compared with controls, cases diagnosed by the presence of cytotoxin or pseudomembranes were found to have been hospitalized longer at diarrhea onset, to have had more antecedent infections, and to have received clindamycin, multiple antimicrobials, and therapeutic antimicrobials more often than controls, but controls received prophylactic antimicrobials more frequently than cases. Cultures of the environment, patients, and personnel failed to detect a mechanism of acquisition. |
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Authors:
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D N Gerding; M M Olson; L R Peterson; D G Teasley; R L Gebhard; M L Schwartz; J T Lee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 146 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-01-24 Completed Date: 1986-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / adverse effects Clostridium / isolation & purification Clostridium Infections* / diagnosis Cross Infection / diagnosis, etiology* Cytotoxins / analysis Diarrhea / diagnosis, etiology* Endoscopy Enterocolitis, Pseudomembranous / diagnosis, etiology* Feces / microbiology Female Humans Male Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cytotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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