| Clostridium difficile Carriage in Healthy Infants in the Community: a Potential Pathogenic Strain Reservoir. | |
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MedLine Citation:
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PMID: 22843784 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Clostridium difficile has been considered for a long time as nosocomial, but now has emerged in the community. During infancy, asymptomatic C. difficile colonization is common. However, knowledge of colonization determinants and strain characteristics is limited. We studied the dynamics of C. difficile colonization in healthy infants from the community. Determinants of the colonization and strain genotypes were also determined on a cohort of infants attending day nurseries.Methods. A one-year follow-up study was performed in ten healthy infants to determine the incidence and kinetics of intestinal C. difficile colonization. In addition, a one-point study was performed in 85 healthy infants (0-3 years) from two day nurseries. C. difficile isolates were PCR-ribotyped and analyzed for the presence of toxin genes.Results. During the follow-up study, all the infants acquired C. difficile and were colonized for several months. An early (neonatal) and a late (4-6 months of age) acquisition period were identified. In day nurseries, 38 infants (45%) carried C. difficile with 11 (13%) carrying a toxigenic isolate. Age and several environmental factors were associated with the C. difficile carrier-state. Adult disease-causing strains were identified in infants. Interestingly, no infant carried the common epidemic 027 or 078 strains.Conclusions. This study provides information on the dynamics of colonization in infants in the community and on the genotype of involved strains. C. difficile colonization appears mainly as an age-dependent process. Pathogenic strains circulate in asymptomatic infants from the community who represent a potential reservoir of pathogenic strains. |
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Authors:
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Clotilde Rousseau; Isabelle Poilane; Loic De Pontual; Anne-Claire Maherault; Alban Le Monnier; Anne Collignon |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-25 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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EA 4043, USC INRA, Ecosystème Microbien Digestif et Santé, Faculté de pharmacie, Université Paris Sud-11, Châtenay-Malabry, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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