Document Detail


Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration.
MedLine Citation:
PMID:  21459564     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bacterial C3 exoenzymes are widely used tools to investigate cellular events influenced by small GTPases of the Rho subfamily. In this respect they have gained increasing interest in addressing questions dealing with the neuronal morphogenic program during development and after lesion of the mature nervous system. Since central neurons display only very limited capacity to re-grow their axons after injury, successful strategies to improve regeneration are much sought-after. For a long time exclusively considered to be Rho-inhibiting exoenzymes, there is now accumulating evidence that C3 proteins of clostridial sources exhibit their often beneficial effects on neurite outgrowth by other means than ADP-ribosylation. The current review will outline previous attempts to foster neuronal cell growth by the use of C3 transferases and highlight the more recent approaches to improve regenerative axon outgrowth using enzyme-deficient C3 preparations.
Authors:
Markus Höltje; Ingo Just; Gudrun Ahnert-Hilger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-1
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  -     ISSN:  1618-0402     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier GmbH. All rights reserved.
Affiliation:
Centrum für Anatomie, Institut für Integrative Neuroanatomie, AG Funktionelle Zellbiologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Germany.
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