Document Detail

Closing volume during normal pregnancy.
MedLine Citation:
PMID:  694802     Owner:  NLM     Status:  MEDLINE    
Serial lung function studies were performed in ten healthy, primiparous women aged 21--28. Measurements were made at two-monthly intervals during pregnancy and included functional residual capacity (FRC), total lung capacity (TLC), vital capacity (VC), specific conductance (SGaw) and closing volume (CV) on each occasion. Closing volume expressed as formular: (see text), showed a progressive rise during pregnancy in all subjects with a linear relationship to time (P less than 0.001, P greater than 0.01, respectively). No consistent changes in lung volume could be shown during pregnancy over the study period. It is suggested that the increase in closing volume during pregnancy might result in abnormalities of distribution of ventilation sufficient to explain the maternal blood gas disturbances of pregnancy.
G S Garrard; W A Littler; C W Redman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  33     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  488-92     Citation Subset:  IM    
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MeSH Terms
Closing Volume*
Dyspnea / complications
Lung Volume Measurements*
Pregnancy Complications
Time Factors
Ventilation-Perfusion Ratio

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