| Closing in on the pathogenesis of the 5q- syndrome. | |
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MedLine Citation:
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PMID: 20469997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evaluation of: Barlow JL, Drynan LF, Hewett DR et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat. Med. 16(1), 59-66 (2010); and Starczynowski DT, Kuchenbauer F, Argiropoulos B et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat. Med. 16(1), 49-58 (2009). Patients with 5q- syndrome are characterized by macrocytic anemia, normal to elevated platelet counts, and a propensity to develop acute myeloid leukemia. The 5q- syndrome is believed to be a clonal disorder of the hematopoietic precursors. Until recently, little was known regarding the molecular pathogenesis of this malignancy. Two recently published studies using genetic approaches have unraveled a small array of genes whose alteration recapitulates critical features of the 5q- syndrome including dysplasia, clonal dominance, and progression to acute myeloid leukemia. |
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Authors:
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Sean M Post; Alfonso Quintás-Cardama |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of anticancer therapy Volume: 10 ISSN: 1744-8328 ISO Abbreviation: Expert Rev Anticancer Ther Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101123358 Medline TA: Expert Rev Anticancer Ther Country: England |
Other Details:
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Languages: eng Pagination: 655-8 Citation Subset: IM |
Affiliation:
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University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1010, Houston, TX 77030, USA. spost@mdanderson.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Macrocytic
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diagnosis,
etiology*,
genetics*,
pathology Animals Chromosomes, Human, Pair 5 / genetics* Gene Deletion Genes, p53 / genetics Humans Leukemia, Myeloid, Acute / diagnosis, etiology*, genetics*, pathology Myelodysplastic Syndromes / diagnosis, etiology, genetics, pathology Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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