| Closed loop control of sedation for colonoscopy using the Bispectral Index. | |
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MedLine Citation:
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PMID: 12109414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen patients undergoing colonoscopy were sedated with propofol using a closed-loop control system guided by the Bispectral Index (BIS). Propofol administration, via a target-controlled infusion, was controlled by a proportional-integral-differential control algorithm. The median (range) propofol target concentration during closed-loop control was 2.3 (1.7-3.6) microg.ml(-1). The performance characteristics of the system were excellent, with a median absolute performance error of 7 (1-15). Patients were drowsy yet rousable, with a median (range) BIS set-point of 80 (75-85). No patient became apnoeic, required airway support or became haemodynamically unstable whilst sedated. Eight patients moaned or moved during colonoscopy and four had recall. Median (range) time to full consciousness was 4 (2-20) min after the end of closed-loop control. Patient and surgeon satisfaction were high. We conclude that BIS may be a suitable control variable for closed-loop control of sedation with propofol. |
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Authors:
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K Leslie; A Absalom; G N C Kenny |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 57 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2002-07-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 693-7 Citation Subset: AIM; IM |
Affiliation:
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University Department of Anaesthesia, Southern General Hospital, Glasgow, Scotland, UK. kate.leslie@mh.org.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Anesthesia, Closed-Circuit* Anesthetics, Intravenous / administration & dosage Colonoscopy* Conscious Sedation / methods* Electroencephalography / drug effects* Female Humans Hypnotics and Sedatives / administration & dosage* Infusions, Intravenous Male Middle Aged Monitoring, Intraoperative / methods Propofol / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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