Document Detail

Closed loop control of sedation for colonoscopy using the Bispectral Index.
MedLine Citation:
PMID:  12109414     Owner:  NLM     Status:  MEDLINE    
Sixteen patients undergoing colonoscopy were sedated with propofol using a closed-loop control system guided by the Bispectral Index (BIS). Propofol administration, via a target-controlled infusion, was controlled by a proportional-integral-differential control algorithm. The median (range) propofol target concentration during closed-loop control was 2.3 (1.7-3.6) The performance characteristics of the system were excellent, with a median absolute performance error of 7 (1-15). Patients were drowsy yet rousable, with a median (range) BIS set-point of 80 (75-85). No patient became apnoeic, required airway support or became haemodynamically unstable whilst sedated. Eight patients moaned or moved during colonoscopy and four had recall. Median (range) time to full consciousness was 4 (2-20) min after the end of closed-loop control. Patient and surgeon satisfaction were high. We conclude that BIS may be a suitable control variable for closed-loop control of sedation with propofol.
K Leslie; A Absalom; G N C Kenny
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  57     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-10     Completed Date:  2002-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-7     Citation Subset:  AIM; IM    
University Department of Anaesthesia, Southern General Hospital, Glasgow, Scotland, UK.
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MeSH Terms
Anesthesia, Closed-Circuit*
Anesthetics, Intravenous / administration & dosage
Conscious Sedation / methods*
Electroencephalography / drug effects*
Hypnotics and Sedatives / administration & dosage*
Infusions, Intravenous
Middle Aged
Monitoring, Intraoperative / methods
Propofol / administration & dosage
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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