Document Detail

Closed-loop control of respiratory drive using pressure-support ventilation: target drive ventilation.
MedLine Citation:
PMID:  15665323     Owner:  NLM     Status:  MEDLINE    
By using diaphragm electrical activity (multiple-array esophageal electrode) as an index of respiratory drive, and allowing such activity above or below a preset target range to indicate an increased or reduced demand for ventilatory assistance (target drive ventilation), we evaluated whether the level of pressure-support ventilation can be automatically adjusted in response to exercise-induced changes in ventilatory demand. Eleven healthy individuals breathed through a circuit (18 cm H2O/L/second inspiratory resistance at 1 L/second flow; 0.5-1.0 L/second expiratory flow limitation) connected to a modified ventilator. Subjects breathed for 6-minute periods at rest and during 20 and 40 W of bicycle exercise, with and without target drive ventilation (the target was set to 60% of the increase in diaphragm electrical activity observed between rest and 20 W of unassisted exercise). With target drive ventilation during exercise, the level of pressure-support ventilation was automatically increased, reaching 13.3 +/- 4.0 and 20.3 +/- 2.8 cm H2O during 20- and 40-W exercise, respectively, whereas diaphragm electrical activity was reduced to a level within the target range. Both diaphragmatic pressure-time product and end-tidal CO2 were significantly reduced with target drive ventilation at the end of the 20- (p < 0.01) and 40-W (p < 0.001) exercise periods. Minute ventilation was not altered. These results demonstrate that target drive ventilation can automatically adjust pressure-support ventilation, maintaining a constant neural drive and compensating for changes in respiratory demand.
Jadranka Spahija; Jennifer Beck; Michel de Marchie; Alain Comtois; Christer Sinderby
Related Documents :
1905613 - Normal values and ranges for ventilation and breathing pattern at maximal exercise.
8222823 - Mechanical insufflation-exsufflation. comparison of peak expiratory flows with manually...
8950073 - Hemodynamic effects of intravenous elgodipine in coronary artery disease during rest an...
Publication Detail:
Type:  Journal Article     Date:  2005-01-21
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  171     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1009-14     Citation Subset:  AIM; IM    
Research Center, Respiratory Health Research Unit, Sacré-Coeur Hospital of Montreal, Canada H4J 1C5.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diaphragm / innervation
Middle Aged
Oxygen Consumption
Pulmonary Gas Exchange
Respiration, Artificial*
Respiratory Muscles / physiopathology
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of high versus low positive end-expiratory pressures in acute respiratory distress syndrome.
Next Document:  Characteristics of physical activities in daily life in chronic obstructive pulmonary disease.