Document Detail

Closed head injury increases extracellular levels of antioxidants in rat hippocampus in vivo: an adaptive mechanism?
MedLine Citation:
PMID:  11744229     Owner:  NLM     Status:  MEDLINE    
Reactive oxygen species (ROS) are a major cause of secondary brain injury following head trauma. Low molecular weight antioxidants (LMWA) protect the tissue against oxidative damage caused by ROS. In the present study, we measured the extracellular levels of the LMWA ascorbic acid and uric acid in the rat brain before, during and after experimental closed head injury (CHI). A dialysis probe was inserted into the right ventral hippocampus through a chronically implanted guide. CHI was applied to the left hemisphere using a weight-drop device. CHI induced a rapid but transient increase in ascorbic acid levels. Uric acid levels increased to 250% of baseline shortly after CHI and remained elevated at 2 h after CHI. Previous results show that the overall reducing power of brain tissue decreases following CHI. Together with previous results, the current findings suggest that ascorbic acid and uric acid are mobilized from brain cells to the extracellular space.
E Moor; R Kohen; R J Reiter; E Shohami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  316     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Department of Pharmacology, The Hebrew University of Jerusalem, The School of Pharmacy, Hadassah Ein Kerem, Jerusalem 91120, Israel.
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MeSH Terms
Antioxidants / metabolism*
Ascorbic Acid / metabolism
Brain Injuries / metabolism*,  pathology,  physiopathology
Extracellular Space / metabolism*
Head Injuries, Closed / metabolism*,  pathology,  physiopathology
Hippocampus / metabolism*,  pathology,  physiopathology
Neurons / metabolism*,  pathology
Oxidative Stress / physiology
Rats, Inbred Strains
Reactive Oxygen Species / metabolism
Up-Regulation / physiology*
Uric Acid / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid

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