| Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon. | |
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MedLine Citation:
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PMID: 18077678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a cooperation between the neural adhesion molecule close homolog of L1 (CHL1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area-specific thalamocortical projections. CHL1 deletion in mice selectively disrupted the projection of somatosensory thalamic axons from the ventrobasal (VB) nuclei, causing them to shift caudally and target the visual cortex. At the ventral telencephalon, an intermediate target with graded Sema3A expression, VB axons were caudally shifted in CHL1- embryos and in Npn1(Sema-/-) mutants, in which axons are nonresponsive to Sema3A. CHL1 colocalized with Npn1 on thalamic axons, and associated with Npn1 through a sequence in the CHL1 Ig1 domain that was required for Sema3A-induced growth cone collapse. These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections. |
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Authors:
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Amanda G Wright; Galina P Demyanenko; Ashton Powell; Melitta Schachner; Lilian Enriquez-Barreto; Tracy S Tran; Franck Polleux; Patricia F Maness |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 27 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 13667-79 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / physiology* Cell Adhesion Molecules / genetics, physiology* Crosses, Genetic Growth Cones / physiology Mice Mice, Mutant Strains Mice, Transgenic Neural Pathways / cytology, embryology, physiology* Neuropilin-1 / genetics, physiology* Protein Structure, Tertiary / physiology Telencephalon / cytology, embryology, physiology* Thalamus / cytology, embryology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MH064056/MH/NIMH NIH HHS; NS049109/NS/NINDS NIH HHS; P30NS0445892/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Chl1 protein, mouse; 144713-63-3/Neuropilin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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