| Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions. | |
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MedLine Citation:
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PMID: 10407109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls. |
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Authors:
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W F Maragos; P A Tillman; M D Chesnut; R J Jakel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 834 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-10 Completed Date: 1999-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 168-72 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Elsevier Science B.V. |
Affiliation:
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Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clorgyline / pharmacology* Corpus Striatum / drug effects*, pathology* Electron Transport Complex II Male Malonates / pharmacology* Mitochondria / drug effects Monoamine Oxidase Inhibitors / pharmacology* Multienzyme Complexes / antagonists & inhibitors Neurotoxins / pharmacology Nitro Compounds Oxidoreductases / antagonists & inhibitors Propionic Acids / pharmacology* Rats Rats, Sprague-Dawley Reference Values Selegiline / pharmacology* Succinate Dehydrogenase / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
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NS01941/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Malonates; 0/Monoamine Oxidase Inhibitors; 0/Multienzyme Complexes; 0/Neurotoxins; 0/Nitro Compounds; 0/Propionic Acids; 141-82-2/malonic acid; 14611-51-9/Selegiline; 17780-72-2/Clorgyline; 504-88-1/3-nitropropionic acid; EC 1.-/Oxidoreductases; EC 1.3.5.1/Electron Transport Complex II; EC 1.3.99.1/Succinate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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