Document Detail


Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
MedLine Citation:
PMID:  10407109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls.
Authors:
W F Maragos; P A Tillman; M D Chesnut; R J Jakel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  834     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  168-72     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Affiliation:
Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clorgyline / pharmacology*
Corpus Striatum / drug effects*,  pathology*
Electron Transport Complex II
Male
Malonates / pharmacology*
Mitochondria / drug effects
Monoamine Oxidase Inhibitors / pharmacology*
Multienzyme Complexes / antagonists & inhibitors
Neurotoxins / pharmacology
Nitro Compounds
Oxidoreductases / antagonists & inhibitors
Propionic Acids / pharmacology*
Rats
Rats, Sprague-Dawley
Reference Values
Selegiline / pharmacology*
Succinate Dehydrogenase / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
NS01941/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Malonates; 0/Monoamine Oxidase Inhibitors; 0/Multienzyme Complexes; 0/Neurotoxins; 0/Nitro Compounds; 0/Propionic Acids; 141-82-2/malonic acid; 14611-51-9/Selegiline; 17780-72-2/Clorgyline; 504-88-1/3-nitropropionic acid; EC 1.-/Oxidoreductases; EC 1.3.5.1/Electron Transport Complex II; EC 1.3.99.1/Succinate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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