Document Detail


Clopidogrel: a review of its use in the prevention of atherothrombosis.
MedLine Citation:
PMID:  10983738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Clopidogrel was significantly more effective than aspirin in the prevention of vascular events (ischaemic stroke, myocardial infarction or vascular death) [corrected] in patients with atherothrombotic disease manifested by recent myocardial infarction, recent ischaemic stroke or symptomatic peripheral arterial occlusive disease [corrected] in the CAPRIE study. The overall tolerability profile of the drug was similar to that of aspirin, although gastrointestinal haemorrhage occurred significantly less often in clopidogrel recipients. The drug is widely used in combination with aspirin for the prevention of atherothrombosis after placement of intravascular stents, and available data suggest that this combination is as effective as ticlopidine plus aspirin for this indication.
Authors:
B Jarvis; K Simpson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  60     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-01-02     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  347-77     Citation Subset:  IM    
Affiliation:
Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / drug therapy*
Clinical Trials as Topic
Drug Interactions
Humans
Platelet Activation / drug effects
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / therapeutic use*
Purinergic P2 Receptor Antagonists*
Stents
Thrombosis / prevention & control*
Ticlopidine / analogs & derivatives*,  pharmacokinetics,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Purinergic P2 Receptor Antagonists; 55142-85-3/Ticlopidine; A74586SNO7/clopidogrel
Comments/Corrections
Erratum In:
Drugs 2001;61(1):52

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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