| Clopidogrel as adjunctive antiplatelet therapy during coronary stenting. | |
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MedLine Citation:
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PMID: 10588198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We examined the procedural and 30-day clinical outcomes among patients receiving aspirin and either ticlopidine or clopidogrel during coronary stenting. BACKGROUND: Ticlopidine-plus-aspirin has become standard antiplatelet therapy for the prevention of thrombotic complications after coronary stenting. Clopidogrel has a similar mechanism of action as ticlopidine, but both its efficacy and its safety as a pharmacologic adjunct to coronary stenting have not been well described. METHODS: This single-center, prospective analysis examined the in-hospital procedural and 30-day clinical outcomes among 875 consecutive patients undergoing coronary stenting who received adjunctive aspirin and either clopidogrel (n = 514; 58.7%) or ticlopidine (n = 361; 41.3%) therapy. RESULTS: Procedural success rates were similar among the clopidogrel- (99.6%) and ticlopidine-treated patients (99.4%). Subacute stent thrombosis (i.e., >24 h < or =30 days) occurred in one clopidogrel-treated (0.2%) and in one ticlopidine-treated (0.3%) patient (p = 0.99). By 30 days following the index procedure, the combined rates of death, nonfatal myocardial infarction and need for target vessel revascularization were similar among patients who received either clopidogrel (2.1%) or ticlopidine (1.4%; p = 0.57) therapy. CONCLUSIONS: In this analysis the antiplatelet combination therapy of aspirin-plus-clopidogrel was an effective regimen for preventing thrombotic complications and major adverse cardiovascular events among a broad spectrum of patients undergoing coronary artery stenting. |
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Authors:
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G J Mishkel; F V Aguirre; R W Ligon; K J Rocha-Singh; C L Lucore |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 34 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 1999-12-17 Completed Date: 1999-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1884-90 Citation Subset: AIM; IM |
Affiliation:
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Prairie Educational and Research Cooperative, Division of Cardiology, Southern Illinois University School of Medicine, Springfield, USA. pccl@fgi.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Angioplasty, Transluminal, Percutaneous Coronary / methods Aspirin / administration & dosage, therapeutic use* Coronary Angiography Coronary Thrombosis / etiology, prevention & control* Drug Therapy, Combination Female Hospital Mortality Humans Length of Stay Male Middle Aged Odds Ratio Platelet Aggregation Inhibitors / administration & dosage, therapeutic use* Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors Prospective Studies Safety Stents* / adverse effects Ticlopidine / administration & dosage, analogs & derivatives*, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 1999 Dec;34(7):1895-8
[PMID:
10588200
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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