Document Detail

Clopidogrel as adjunctive antiplatelet therapy during coronary stenting.
MedLine Citation:
PMID:  10588198     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We examined the procedural and 30-day clinical outcomes among patients receiving aspirin and either ticlopidine or clopidogrel during coronary stenting. BACKGROUND: Ticlopidine-plus-aspirin has become standard antiplatelet therapy for the prevention of thrombotic complications after coronary stenting. Clopidogrel has a similar mechanism of action as ticlopidine, but both its efficacy and its safety as a pharmacologic adjunct to coronary stenting have not been well described. METHODS: This single-center, prospective analysis examined the in-hospital procedural and 30-day clinical outcomes among 875 consecutive patients undergoing coronary stenting who received adjunctive aspirin and either clopidogrel (n = 514; 58.7%) or ticlopidine (n = 361; 41.3%) therapy. RESULTS: Procedural success rates were similar among the clopidogrel- (99.6%) and ticlopidine-treated patients (99.4%). Subacute stent thrombosis (i.e., >24 h < or =30 days) occurred in one clopidogrel-treated (0.2%) and in one ticlopidine-treated (0.3%) patient (p = 0.99). By 30 days following the index procedure, the combined rates of death, nonfatal myocardial infarction and need for target vessel revascularization were similar among patients who received either clopidogrel (2.1%) or ticlopidine (1.4%; p = 0.57) therapy. CONCLUSIONS: In this analysis the antiplatelet combination therapy of aspirin-plus-clopidogrel was an effective regimen for preventing thrombotic complications and major adverse cardiovascular events among a broad spectrum of patients undergoing coronary artery stenting.
G J Mishkel; F V Aguirre; R W Ligon; K J Rocha-Singh; C L Lucore
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  34     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-17     Completed Date:  1999-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1884-90     Citation Subset:  AIM; IM    
Prairie Educational and Research Cooperative, Division of Cardiology, Southern Illinois University School of Medicine, Springfield, USA.
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MeSH Terms
Administration, Oral
Angioplasty, Transluminal, Percutaneous Coronary / methods
Aspirin / administration & dosage,  therapeutic use*
Coronary Angiography
Coronary Thrombosis / etiology,  prevention & control*
Drug Therapy, Combination
Hospital Mortality
Length of Stay
Middle Aged
Odds Ratio
Platelet Aggregation Inhibitors / administration & dosage,  therapeutic use*
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
Prospective Studies
Stents* / adverse effects
Ticlopidine / administration & dosage,  analogs & derivatives*,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel
Comment In:
J Am Coll Cardiol. 1999 Dec;34(7):1895-8   [PMID:  10588200 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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