Document Detail


Clopidogrel pharmacogenetics and its clinical implications.
MedLine Citation:
PMID:  19636246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacogenetics encompasses a range of phenomena ranging from pharmacology to therapeutics to toxicology and generally focuses on the study of genetic factors related to interindividual variability in drug response. Individual differences in the rate of platelet reactivity markedly influence normal hemostasis and the pathologic outcome of thrombosis. Response to clopidogrel varies widely, with nonresponse rates in various studies ranging from 4%-30% at 24 hours. Polymorphism involved in the response to antithrombotic drugs has been described in components of the hemostatic and thrombotic systems, and these include genetic variations. Polymorphisms in the hepatic enzymes involved in the metabolism of clopidogrel (e.g., CYP 1A2, CYP3A4, CYP2C19) or within the platelet membrane receptor (P2Y12) and/or polymorphism of platelet integrin alphaIIbbeta3 or integrin alpha2beta1 may affect platelet responses and could influence response to clopidogrel administration. In this review, we discuss the pharmacogenetics of clopidogrel related to the phenomenon of response variability and its clinical implications.
Authors:
Mukesh Singh; Bipin Thapa; Rohit Arora
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of therapeutics     Volume:  17     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e66-73     Citation Subset:  IM    
Affiliation:
Section of Cardiology, Department of Internal Medicine, Rosalind Franklin University of Medicine & Science, Chicago Medical School, North Chicago, IL, USA. drmukeshsingh@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Blood Platelets / drug effects,  metabolism
Cytochrome P-450 Enzyme System / genetics,  metabolism
Humans
Integrin alpha2beta1 / genetics,  metabolism
Pharmacogenetics*
Platelet Aggregation Inhibitors / metabolism,  pharmacology*
Platelet Glycoprotein GPIIb-IIIa Complex / genetics,  metabolism
Polymorphism, Genetic
Receptors, Purinergic P2 / genetics
Ticlopidine / analogs & derivatives*,  metabolism,  pharmacology
Chemical
Reg. No./Substance:
0/Integrin alpha2beta1; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; 0/Receptors, Purinergic P2; 0/purinoceptor P2Y12; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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