Document Detail

Clopidogrel: The Data, the Experience, and the Controversies.
MedLine Citation:
PMID:  23057989     Owner:  NLM     Status:  Publisher    
Dual antiplatelet therapy with acetylsalicylic acid (aspirin) and clopidogrel is a guideline-recommended standard of care for patients with acute coronary syndromes (ACS) and those who undergo percutaneous coronary intervention (PCI). Despite a large body of clinical evidence obtained from randomized clinical trials and patient registries supporting the efficacy and safety of aspirin plus clopidogrel therapy in these patients, questions concerning the optimal use of dual antiplatelet therapy remain. Widely debated topics pertaining to dual antiplatelet therapy in patients with ACS or undergoing PCI include (i) the appropriate clopidogrel loading dose; (ii) the optimal time to initiate the clopidogrel loading dose; (iii) the optimal duration of dual antiplatelet therapy following ACS or PCI; (iv) impact of variability of platelet response on patient outcomes; and (v) the role of other recommended and emerging P2Y(12) antagonists. This review discusses these ongoing controversies regarding the optimal use of dual antiplatelet therapy with aspirin and clopidogrel in patients with ACS or those undergoing PCI.
Saihari Sadanandan; Inder M Singh
Related Documents :
24654609 - Networks for improving care in patients with acute coronary syndrome: a framework.
11158819 - Uveitis masquerade syndromes.
6605449 - Heterogeneity of t-cell neoplasias as defined by monoclonal antibodies.
12894069 - Large b-cell lymphoma of the leg: clinical and pathologic characteristics in a north am...
6850509 - Hydrocele formation in patients with hodgkin's disease.
15818649 - Positron emission tomography (pet): evaluation of chronic periaortitis.
1424299 - Response of plasma renin-angiotensin system to a single captopril administration in pat...
11839879 - Long-term survival following radiofrequency catheter ablation of atrioventricular junct...
3962639 - Mortality after cervical hip fracture. 3002 patients followed for 6 years.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  American journal of cardiovascular drugs : drugs, devices, and other interventions     Volume:  -     ISSN:  1179-187X     ISO Abbreviation:  Am J Cardiovasc Drugs     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100967755     Medline TA:  Am J Cardiovasc Drugs     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Indiana University Health, Indianapolis, IN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Unexpected seasonal variation in offspring size and performance in a viviparous ectoparasite.
Next Document:  Periodontal therapy decreases serum levels of adipocyte fatty acid-binding protein in systemically h...